INFOGRAPHIC: ENVISION study

Narrated by a patient with AIP

Attacks

Chronic symptoms

Narrated by a patient with AIP

Pain
Headache

Seizures
Sun sensitivity

Nausea
Vomiting

Constipation
Diarrhea

Muscle weakness
Paralysis

Sensory loss
Rapid heartbeat

Trouble sleeping
Fatigue

Anxiety
Depression

Memory loss
Confusion

Not all symptoms of AHP shown

Narrated by a patient with AIP

Narrated by a patient with AIP

A picture of a thermometer with text on the side

Narrated by a patient with AIP

Introduction

General health

Current effect of health on activities

Effect of physical health on work or activities in the past 4 weeks

The 12-item Short Form Health Survey (SF-12) version 2 Physical Component Summary (PCS) score

An increase in PCS score of 2-5 has been considered ‘clinically meaningful’ in other chronic diseases

Health, ranging from excellent to poor

Limit to activities such as pushing a vacuum cleaner, moving a table, or bowling owing to health, ranging from limited a lot to not limited at all
Limit to climbing several flights of stairs, ranging from limited a lot to not limited at all

Whether physical health limited the kind of work/activities performed
Whether physical health limited accomplishments
Interference of pain in normal work, ranging from no interference to extreme enterference

HRQoL improved over time with givosiran treatment

Narrated by Dr Bruce Wang, the oral presenter

HRQoL improved over time with givosiran treatment

Narrated by Dr Bruce Wang, the oral presenter

Long-term clinical outcomes of patients with acute hepatic porphyria who were not attack-free after 6 months of givosiran treatment: a subgroup analysis of the phase 3 ENVISION study

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